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Flying Dutchman said..
Thanks for replying fangman & D3.
Yup they are all good points. I guess I found this study interesting because we were led to believe that 50+ year old covid vaxxed people were 7-10 times more likely to not die than the unvaccinated according to Remery's studies and various media outlets over the years. This particular study paints a very different picture.
This review is a more in depth investigation an cites the paper you provided.
www.ncbi.nlm.nih.gov/pmc/articles/PMC10973921/"Interestingly, this IgG4 production was detected following SARS-CoV-2 infection and after administration of anti-COVID-19 products, perfectly suggesting both the allergenic and tolerogenic side of the Spike protein and, thus, the production of this type of antibody by repeated exposure to this viral component [260-263]."
I haven't read the whole review but it seems to be suggesting induced immune tolerance.
Getting back to the paper you presented; you left this part out of their conclusion...
"This finding raises the possibility that an aberrant immunopathological response to vaccination in a subset of patients might have contributed to the inadequate response to COVID-19 vaccines. This speculative observation warrants additional research regarding heterogeneous host responses to vaccination. It is also important to note that overall frailty is recognized as a reliable predictor of clinical outcomes of COVID-19 followed by age and comorbidities. However, elderly, and those with various comorbid conditions and increased frailty index, were not adequately represented in the conducted clinical COVID-19 vaccine trials. This significant omission is highlighted by our current and other similar studies and suggest the need for better vaccines or other therapies for certain at-risk populations."
It seems to me, and I might be wrong, that both papers are saying that a small number of frail people may not get the hoped-for protection from the vaccine, and that, if they get COVID, they may die of COVID not the vaccine.I'm happy to be corrected with intelligent discourse, ie, not a meme.