C19: IVM V.D HCQ V.C Zn PVP-I REGN LY RMDShare Tweet MetaDownload ImageShare Tweet Early?85%49 ivermectin studies
18 peer reviewed
Early treatment and prophylaxis is effective100% of studies report positive effects. 85% improvement from meta analysis, p50 or comorbidities, showing 2.2% hospitalization and 0.3% death, which authors note is considerably lower than reported in other studies in their region. At least two of z..12/27MetaHill, A., Preprint (Preprint) (meta analysis)meta-analysisMeta-analysis of clinical trials of ivermectin to treat COVID-19 infectionWHO-funded meta analysis showing ivermectin treatment mortality relative risk RR 0.17 [0.08-0.35] for RCTs and RR 0.28 [0.13-0.62] for RCTs and observational studies, and confirming a dose-response effect.12/24In VitroJeffreys et al., bioRxiv, doi:10.1101/2020.12.23.424232 (Preprint) (In Vitro)in vitroRemdesivir-Ivermectin combination displays synergistic interaction with improved in vitro antiviral activity against SARS-CoV-2In Vitro study showing enhanced antiviral activity of ivermectin and remdesivir in combination.12/20PrEPPEPVallejos et al. (News)cases, ?78.6%, p 0.05. Negative PCR results were not signific..8/28PrEPPEPShouman et al., NCT04422561 (Preprint)symp. case, ?91.3%, p<0.001Use of Ivermectin as a Prophylactic Option in Asymptomatic Family Close Contacts with Patients of COVID-19PEP trial for asymptomatic close contacts of COVID-19 patients, 203 ivermectin patients and 101 control patients. 7.4% of contacts developed COVID-19 in the ivermectin group vs. 58.4% in the control group, adjusted odds ratio OR 0.087, p ..8/15EarlyEspitia-Hernandez et al., Biomedical Research, 31:5 (Peer Reviewed)viral+, ?97.2%, p<0.0001Effects of Ivermectin-azithromycin-cholecalciferol combined therapy on COVID-19 infected patients: A proof of concept studySmall study with 28 patients treated with ivermectin + AZ + cholecalciferol and 7 control patients. All treated patients were PCR- at day 10 while all control patients remained PCR+. The mean duration of symptoms was 3 days in the treatm..8/14LateBhattacharya et al., Int. J. Scientific Research, doi:10.36106/ijsr/7232245 (Peer Reviewed)Observational Study on Clinical Features, Treatment and Outcome of COVID 19 in a tertiary care Centre in India- a retrospective case seriesRetrospective 148 hospitalized patients showing triple therapy with ivermectin + atorvastatin + N-acetylcysteine resulted in a 1.35% case fatality rate which was well below the national average.7/31LateChang et al., ResearchGate (Preprint)Post-acute or prolonged COVID-19: ivermectin treatment for patients with persistent symptoms or post-acute symptomsReport on 33 patients with persistent or post-acute symptoms treated with ivermectin, showing a high rate of clinical improvement.7/31TheoryChang et al., ResearchGate, doi:10.13140/RG.2.2.34561.48483/2 (Preprint) (Theory)theoryCOVID-19: Post-exposure prophylaxis with ivermectin in contacts. At Homes, Places of Work, Nursing Homes, Prisons, and OthersProposed PEP protocol based on ivermectin.7/31LateAlam et al., Journal of Bangladesh College of Physicians and Surgeons, doi:10.3329/jbcps.v38i0.47512 (Peer Reviewed)A Case Series of 100 COVID-19 Positive Patients Treated with Combination of Ivermectin and DoxycyclineCase study of 100 patients treated with ivermectin and doxycycline, with no ICU admission, deaths, or serious side effects reported.7/31LateRahman et al., J. Bangladesh Coll. Phys. Surg. 38, 5-9, doi:10.3329/jbcps.v38i0 (Peer Reviewed)Comparison of Viral Clearance between Ivermectin with Doxycycline and Hydroxychloroquine with Azithromycin in COVID-19 PatientsComparison of 200 patients treated with ivermectin + doxycycline and 200 treated with HCQ + AZ. The HCQ + AZ group had more severe cases at baseline. Viral clearance was faster with ivermectin + doxycycline. Ivermectin dose is given all o..7/14EarlyChowdhury et al., Research Square, doi:10.21203/rs.3.rs-38896/v1 (Preprint)A Randomized Trial of Ivermectin-Doxycycline and Hydroxychloroquine-Azithromycin therapy on COVID19 patientsSmall 116 patient RCT comparing Ivermectin-Doxycycline and HCQ+AZ, not showing a significant difference in time to PCR negative or symptom resolution. Time to symptomatic recovery was 5.93 days for Ivermectin-Doxycycline vs. 6.99 days for..7/8LateGorial et al., medRxiv, doi:10.1101/2020.07.07.20145979 (Preprint)death, ?71.0%, p=1.00Effectiveness of Ivermectin as add-on Therapy in COVID-19 Management (Pilot Trial)Small trial of hospitalized patients with 16 of 87 patients being treated with ivermectin showing a significantly lower mean hospital stay with ivermectin: 7.62 vs. 13.22 days, p=0.00005. 0 of 16 ivermectin patients died vs. 2 of 71 cont..6/30In VitroCaly et al., Antiviral Research, doi:10.1016/j.antiviral.2020.104787 (Peer Reviewed) (In Vitro)in vitroThe FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 in vitroIn Vitro study showing that ivermectin is an inhibitor of SARS-CoV-2, with a single addition to Vero-hSLAM cells 2h post infection with SARS-CoV-2 able to effect ~5000-fold reduction in viral RNA at 48h.6/19TheoryLehrer et al., In Vivo, 34:5, 3023-3026, doi:10.21873/invivo.12134 (Theory)theoryIvermectin Docks to the SARS-CoV-2 Spike Receptor-binding Domain Attached to ACE2In silico analysis showing ivermectin docking which may interfere with the attachment of the spike to the human cell membrane.6/12ReviewHeidary et al., The Journal of Antibiotics, 73, 593-602, doi:10.1038/s41429-020-0336-z (Review) (Peer Reviewed)reviewIvermectin: a systematic review from antiviral effects to COVID-19 complementary regimenReview of the antimicrobial, antiviral, and anti-cancer properties of ivermectin. Antiviral effects have been reported for Zika, dengue, yellow fever, West Nile, Hendra, Newcastle, Venezuelan equine encephalitis, chikungunya, Semliki For..5/2EarlyChang, G., Research Gate, doi:10.13140/RG.2.2.34689.48482/7 (Preprint)Inclusi?n de la ivermectina en la primera l?nea de acci?n terap?utica para COVID-19Peru observational case study of 7 patients treated with ivermectin, showing improvement and resolution of fever within 48 hours, and 100% recovery.