Also depends a lot on the shape and style of both the side and centre fins. If you have a narrow based flexible raked centre fin like A, removing the sides can slow the board down. This style of fin can be aided by having side fins generate more drive creating speed and acceleration. Well worth trying different size side bites v centre. Depending on the board and your goals, you could go anywhere from keeping this big fin with micro bites, or moving on to a proportional regular tri fin arrangement.
On the other hand, if your centre fin is stiffer and has a base with more area like B, it should stand-alone generate a lot of power. With these side fins are unnecessary. The extra drag is likely only to make the board slower and unmanageable. Nevertheless, many people who don't have tree stump thighs like the "twang" they get from a lone big flexible single fin.
Other considerations are the design of the board and your own style. Many boards are designed around the fins. For instance, performance boards typically three and a logger a single. Likewise, are you a power surfer, neutral flow, or still hoping to make the pro division? As the comment above, best thing is to experiment and see what suits the board and you!